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Ciprofloxacin Medicinal Tablets Protected From Moisture , Cipro 500 mg Tablet

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Description

Ciprofloxacin Medicinal Tablets 250MG 500MG 750MG ?Antibiotic 10*1& acute;s / Box

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Ciprofloxacin Tablets??500MG

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COMPOSITION.
Each?Ciprofloxacin Tablets?contains ciprofloxacin??500mg.

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PHARMACOLOGICAL?ACTION:

?Fluoroquinolones bring about their bactericidal action by inhibiting the bacterial DNA gyrase enzyme. DNA gyrase is responsible for continuous introduction of negative supercoils into DNA. This is an ATP dependent reaction that requires both strands of the DNA to be cut to permit passage of a segment of DNA through the break; the break is then resealed. Fluoroquinolones decrease the introduction of negative supercoils into DNA and cause rapid cessation of DNA synthesis by interfering with the propagation of DNA replication.

The antibacterial spectrum of ciprofloxacin includes Gram-negative and Gram-positive organisms?viz.

Ciprofloxacin is well absorbed when given orally with a bioavailability of 70%. The mean peak plasma concentrations achieved after oral administration of 250?mg, 500?mg and 750?mg of ciprofloxacin are 1.2?mcg/mL, 2.4?mcg/mL and 4.3?mcg/mL respectively, achieved within 1-2?hours of administration. Absorption is delayed when ciprofloxacin is given with a meal.

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INDICATIONS:

Ciprofloxacin?is indicated for the treatment of the following infections caused by ciprofloxacin sensitive bacteria:
Lower Respiratory Tract Infections

Urinary Tract Infections?

Skin and Soft Tissue Infections

Gastro-intestinal Infections

Bone Infections

Gonorrhoea

In the treatment of infections caused by?Pseudomonas aeruginosa, an aminoglycoside must be administered concomitantly.

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CONTRA-INDICATIONS:

Safety during pregnancy and lactation has not been established.
Ciprofloxacin is contra-indicated in children under 18?years and in growing adolescents, except where the benefits of treatment exceed the risks. Experimental evidence indicates that, species variable, reversible lesions of the cartilage of weight bearing joints has been seen in immature members of certain animal species.
Ciprofloxacin is contra-indicated in patients who have shown hypersensitivity to ciprofloxacin or any other quinolones.

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WARNINGS:

Ciprofloxacin should be used with caution in patients with a history of convulsive disorders.
Crystalluria related to the use of ciprofloxacin has been observed. Patients receiving ciprofloxacin should be well hydrated and excessive alkalinity of the urine should be avoided.

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DOSAGE?AND?DIRECTIONS?FOR?USE:

Ciprofloxacin?tablets should be swallowed whole with plenty of liquid and may be taken with or without meals.
Dosage and duration of treatment: The dosage range is 250-750?mg twice daily.
The duration of treatment depends upon the severity of the infection, clinical response and bacteriological findings.

Infections of the lower respiratory tract: Mild to moderate - 250 to 500?mg twice daily; severe or complicated - 750?mg twice daily. In cystic fibrosis patients the dose is 750?mg twice daily. The low body mass of these patients should, however, be taken into consideration when determining dosage (7.5 to 15?mg/kg/day).
Infectious diarrhoea: 500?mg twice daily.
Infections of the urinary tract: Acute uncomplicated cystitis - 250?mg twice daily; mild to moderate - 250?mg twice daily; severe or complicated - 500?mg twice daily.
Infections of the skin: Mild to moderate - 500?mg twice daily; severe or complicated - 750?mg twice daily.
Bone infections: Mild to moderate 500?mg twice daily; severe or complicated - 750?mg twice daily. Treatment may be required for 4-6?weeks or longer.
Gonorrhoea: A single dose of 250?mg.
Elderly patients should receive a dose as low as possible; this will depend on the severity of the illness and on the creatinine clearance.
Impaired renal or liver function: In patients with reduced renal function, the half-life of ciprofloxacin is prolonged and the dosage needs to be adjusted.



SIDE?EFFECTS?AND?SPECIAL?PRECAUTIONS:
Effects on the gastro-intestinal tract: Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain, flatulence, anorexia.

Effects on the nervous system: Dizziness, headache, tiredness, nervousness, agitation, trembling.?

Reactions of sensory organs

Hypersensitivity reactions

STORAGE?INSTRUCTIONS:

Store below 25°C, protected from moisture.
KEEP OUT OF REACH OF CHILDREN.

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