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Antibiotic Azithromycin Tablets For Curing Pneumonia In Adults 3*1& acute;s / Box 10*1& acute;s / Box

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Description

?Azithromycin Tablets 250MG 500MG ?Antibiotic ?3*1& acute;s / Box ?10*1& acute;s / Box

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Azithromycin Tablets?500MG

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COMPOSITION.
Each?Azithromycin Tablets?contains azithromycin??500mg.

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PHARMACOLOGICAL?ACTION:

?Based?on?animal?models?of?infection,?the?antibacterial?activity?of?azithromycin?appears?to?correlate?with ?the?ratio?of?area?under?the?concentration-?time?curve?to?minimum?inhibitory?concentration?(AUC/MIC)?for ?certain?pathogens?(S.?pneumoniae?and?S.?aureus).?The?principal?pharmacokinetic/pharmacodynamic ?parameter?best?associated?with?clinical?and?microbiological?cure?has?not?been?elucidated?in?clinical?trials ?with?azithromycin.?

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INDICATIONS:

Zithromax?is?a?macrolide?antibacterial?drug?indicated?for?mild?to?moderate?infections?caused?by?designated,?susceptible?bacteria:?

Acute?bacterial?exacerbations?of?chronic?bronchitis?in?adults?

Acute?bacterial?sinusitis?in?adults

Uncomplicated?skin?and?skin?structure?infections?in?adults

Urethritis?and?cervicitis?in?adults?

Genital?ulcer?disease?in?men?

Acute?otitis?media?in?pediatric?patients??

Community-acquired?pneumonia?in?adults?and?pediatric?patients ?

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CONTRA-INDICATIONS:

Patients?with?known?hypersensitivity?to?azithromycin,erythromycin,any?other?macrolide?or?ketolide?antibiotic,or?to?any?component?of?the?product.

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WARNINGS:

Serious?(including?fatal)?allergic?and?skin?reactions:?Discontinue?azithromycin?if?reaction?occurs.??

Hepatotoxicity:?Severe,?and?sometimes?fatal,?hepatotoxicity?has?been?reported,?Discontinue?azithromycin?immediately?if?signs?and?symptoms?of?hepatitis?occur.?

Prolongation?of?QT?interval?and?cases?of?torsades?de?pointes?have?been?reported.?This?risk?which?can?be?fatal?should?be?considered?in?patients?with?certain?cardiovascular?disorders?including?known?QT?prolongation?or?history?torsades?de?pointes,?those?with?proarrhythmic?conditions,?and?with?other?drugs?that?prolong?the?QT?interval.

Clostridium?difficile-associated?diarrhea:?Evaluate?patients?if?diarrhea?occurs.?

Azithromycin?may?exacerbate?muscle?weakness?in?persons?with?myasthenia?gravis.?

?Azithromycin?has?been?reported?to?be?excreted?in?human?breast?milk?in?small?amounts.?Caution?should?be?exercised?when?azithromycin?is?administered?to?a?nursing?woman.?

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DOSAGE?AND?DIRECTIONS?FOR?USE:

Adult?Patients?

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Infection | Recommended?Dose/Duration?of?Therapy |
Community-?acquired?pneumonia?(mild?severity)? Pharyngitis/?tonsillitis?(second-line?therapy)?Skin/skin?structure(uncomplicated) | 500?mg?as?a?single?dose?on?Day?1,? followed?by?250?mg?once?daily?on?Days?2?through?5. |
Acute?bacterial?exacerbations?of?chronic?bronchitis ?(mild?to?moderate) | 500?mg?as?a?single?dose?on?Day?1,? followed?by?250?mg?once?daily?on?Days?2?through?5? or?500?mg?once?daily?for?3?days. |
Acute?bacterial?sinusitis | 500?mg?once?daily?for?3?days. |
Genital?ulcer?disease?(chancroid)?Non-gonococcal?urethritis?and?cervicitis | One?single?1?gram?dose. |
Gonococcal?urethritis?and?cervicitis | One?single?2?gram?dose. |
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Pediatric?Patients?

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Infection | Recommended?Dose/Duration?of?Therapy |
? ?Acute?otitis?media? | 30?mg/kg?as?a?single?dose?or?10?mg/kg?once?daily?for?3?days? or?10?mg/kg?as?a?single?dose?on?Day?1?followed?by?5?mg/kg/day? on?days?2?through?5. |
Acute?bacterial?sinusitis? | 10?mg/kg?once?daily?for?3?days.? |
Community-acquired?pneumonia? | 10?mg/kg?as?a?single?dose?on?Day?1?followed?by?5?mg/kg?once?daily? on?Days?2?through?5.? |
Pharyngitis/tonsillitis? | 12?mg/kg?once?daily?for?5?days.? |
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SIDE?EFFECTS?AND?SPECIAL?PRECAUTIONS:
Gastrointestinal?system?with?diarrhea/loose?stools?(4?to?5%),?nausea?(3%),?and?abdominal?pain?(2?to?3%)?being?the?most?frequently?reported.

Adverse?reactions?that?occurred?with?a?frequency?of?1%?or?less?included?the?following:?

Cardiovascular:?Palpitations,?chest?pain.?Gastrointestinal:?Dyspepsia,?flatulence,?vomiting,?melena,?and?cholestatic?jaundice.?Genitourinary:?Monilia,?vaginitis,?and?nephritis.?Nervous?System:?Dizziness,?headache,?vertigo,?and?somnolence.?General:?Fatigue.?Allergic:?Rash,?pruritus,?photosensitivity,?and?angioedema.?

STORAGE?INSTRUCTIONS:
Store?below?25°C.?Protect?from?light.?Keep?out?of?reach?of?children.

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