Fine Chemicals

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Product Quality

Usage:Adelmidrol could be used in cosmetic,food,dietary supplements.

Introducton of Adelmidrol:

Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats.

Adelmidrol is the International Nonproprietary Name (INN) of a synthetic derivate of azelaic acid, a naturally occurring saturated dicarboxylic acid, that is found in some whole grains and in trace amounts in the human body , its plasma levels normally ranging from 20 to 80 ng/ml. Chemically, ademidrol is the N,N’-bis (2-hydroxyethyl) non anediamide and it is an amphiphilic or amphipathic compound, possessing both hydrophilic and hydrophobic properties, that favour its solubility both in aqueous and organic media.

The physicochemical properties of the compound make it particularly suitable for topical application and an adelmidrol (2%) emulsion has recently shown some benefit in a pilot study on mild atopic dermatitis.

The effect of adelmidrol has been shown to depend, at least in part, on the control of mast cell activation. Densitometric and mor-phometric analyses of skin biopsies from experimental skin wounds showed that treatment with adelmidrol led to an increase in the mast cell granular density, thereby suggesting a decrease in their degranulation . According to chemical structure and cellular mechanism of action, adelmidrol hence belongs to the family of ALIAmides (Autacoid Local Injury Antagonist Amides), i.e. fatty acid amides, whose purported mechanism of action is the down-modulation of mast cell degranulation . Palmitoylethanolamide (PEA) is considered to be the parent molecule of ALIAmides. PEA is naturally present both in animal and vegetable tissues and is able to enhance both the cannabinoid and vanilloid signalling systems , down-regulating the degradation pathways of endo-cannabinoid and endovanilloid compounds . The exact mechanism of action of PEA is not yet well known although PEA may interact with peroxisome proliferator-activated receptor-α, which seems to be involved in some of its anti-inflammatory effects and with the orphan G-protein-coupled receptor GPR55 . The anti-inflammatory and analgesic effects of PEA have been repeatedly reported and are thought to be due, at least in part, to its ability to down-modulate mast cell activation and mast cell mediator release both in vitro and in vivo. Mast cells are highly specialized immune effector cells that, according with their granule content, may be divided into two subpopulations: mucosal mast cells mainly present in the mucosa of respiratory and intestinal tracts, and connective mast cells placed preferentially in skin .