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Description
Modafinil,Alertec,Modavigil,Provigil CAS 68693-11-8
Systematic (IUPAC) name:2-benzhydrylsulfinylethanamide
Clinical data
Trade names Alertec, Modavigil, Modiodal, Provigil, Modalert
AHFS/Drugs.com monograph
MedlinePlus a602016
Licence data US FDA:link
Pregnancy
category
AU: B3
US: C (Risk not ruled out)
Legal status
AU: S4 (Prescription only)
CA: Schedule F
UK: POM (Prescription only)
US: Schedule IV
Dependence
liability Psychological: Very low
Physical: Negligible
Addiction
liability Very low to low
Routes of
administration Oral
Pharmacokinetic data
Bioavailability Not determined due to the aqueous insolubility
Protein binding 62%
Metabolism Hepatic (primarily via amide hydrolysis;CYP1A2, CYP3A4, and CYP2B6)
Biological half-life 15 hours (R-enantiomer),
4 hours (S-enantiomer)
Excretion Urine (80%)
Identifiers
CAS Number 68693-11-8 Yes
ATC code N06BA07
PubChem CID: 4236
IUPHAR/BPS 7555
DrugBank DB00745 Yes
ChemSpider 4088 Yes
UNII R3UK8X3U3D Yes
KEGG D01832 Yes
ChEBI CHEBI:31859
ChEMBL CHEMBL1373 Yes
Chemical data
Formula C15H15NO2S
Molecular mass 273.35 g/mol
Modafinil is a wakefulness-promoting agent (or eugeroic) used for treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea.
It has also seen widespread off-label use as a purported cognition-enhancing agent.
In English-speaking countries it is sold under the brand names Alertec, Modavigil, and Provigil.
In the United States modafinil is classified as a schedule IV controlled substance and restricted in availability and usage, due to concerns about possible addiction potential.
In most other countries it is a prescription drug but not otherwise legally restricted.
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