Chemical Reagent
Description
Active Pharmaceutical Ingredients High Purity Procaine Powder C13H20N2O2
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Procaine
Molecular Formula: C13H20N2O2
CAS number 59-46-1
Monoisotopic mass:236.152481 Da
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
what is Procaine?
It is the first injectable local anesthetic to be synthesized, commonly known as Novocain.The German Chemist, Alfred Einhorn, developed it in 1904.
It works by producing a trigeminal nerve conduction block, in the mandibular (3rd) branch, decreasing the permeability of the axon cell membrane to (Na+) sodium ions.This mechanism prevents the entry of Na+ ions into the axon to propagate an action potential in both slow and fast pain fibers.Unmyelinated axons are the first to be affected.Myelinated motor nerves are only affected at the nodes of Ranvier.Procaine works to anesthetize a patient for about 15 minutes.To prolong anesthesia epinephrine is added as a vasoconstrictor.
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.
Mechanism of action: Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
What plant was procaine derived from?
The coca plant.It is a member of the order Geraniales and the family Erythroxylaceae.Bolivian coca grows in the moist tropical forests of the eastern Andes of Peru and Bolivia. This variety is one of four found growing in the wild. Bolivian coca is the major source of commercially produced coca leaves and cocaine.Procaine is the precursor to cocaine.
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HUBEI PHARMAGRADE STEROIDS co., LTD
Testosterone Anabolic Steroid,Tren Anabolic Steroid,Nandrolone Steroid
Address: Xiaogan Dongshan Shantou Industrial Zone,
Wuhan, Hubei
China, 430000
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