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250MG 500MG Amoxicillin Medicinal Tablets For Respiratory Infections 10*10& acute;s / Box

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?Amoxicillin Medicinal Tablets 250MG 500MG Antibiotic 10*10& acute;s / Box

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AMOXICILLIN?500?MG TABLETS

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COMPOSITION.
Each?Tablet?contains?500?mg?amoxicillin.

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PHARMACOLOGICAL?ACTION:
?Amoxycillin?is?rapidly?absorbed?after?oral?administration?and?provides?high?blood?levels?and?very?high?

concentrations?in?the?tissues?and?urine.?Amoxycillin?does?not?readily?diffuse?into?the?brain?and?spinal?

fluid?except?when?the?meninges?are?inflamed.
The?ingestion?of?food?does?not?greatly?reduce?the?absorption?of?amoxycillin.?Amoxycillin?does?not?appear?

to?be?metabolized?in?the?body.?Urinary?excretion?is?rapid,?and?only?unchanged?amoxycillin?is?recovered?in

?the?urine.?Its?excretion?can?be?delayed?by?concurrent?administration?of?probenecid.?Approximately?17%?

of?amoxycillin?is?bound?by?serum?proteins.

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INDICATIONS:

Amoxycillin?is?indicated?in?the?treatment?of?all?infections?caused?by?susceptible?(non-penicillinase?producing)?micro-organisms.

Respiratory?infections ?

Skin?and?soft?tissue?infections

Gastro-intestinal?infections

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CONTRA-INDICATIONS:

Patients?hypersensitive?to?penicillins?and?cephalosporins.?Patients?with?infectious?mononucleosis?are?

susceptible?to?skin?rashes.

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WARNINGS:

Amoxycillin?may?cause?reactions?typical?of?penicillin?allergy,?especially?in?sensitive?patients.?Should?an?

allergic?reaction?occur,?the?drug?should?be?discontinued?and?the?patient?treated?with?the?usual?agents.

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DOSAGE?AND?DIRECTIONS?FOR?USE:

The?usual?oral?dose?in?Amoxicillin?250?to?500?mg?every?8?hours.?Children?up?to?10?years?of?age?may?be?

given?125?to?250?mg?every?8?hours;?under?20?kg?body?weight?a?dose?of?20?to?40?mg?per?kg?daily?has?

been?suggested.



SIDE?EFFECTS?AND?SPECIAL?PRECAUTIONS:

Side-effects:

Adverse?events?associated?with?amoxycillin?are?allergic?reactions?which?commonly?include?urticarial?or

?maculopapular?skin?rashes.
Amoxycillin?may?cause?reactions?typical?of?penicillin?allergy?in?patients?sensitive?to?penicillin.?

Gastro-?intestinal?adverse?effects?particularly?diarrhoea?and?also?nausea?and?vomiting?occur?quite?

frequently,?usually?following?administration?by?mouth.?Glossitis,?stomatitis?and?black -& quot;hairy& quot;?tongue?have?been?reported.?Pseudomembranous?colitis?has?also?been?reported.?Supra-infections?with?non-susceptible?organisms?may?occur?particularly?with?prolonged?use.

Precautions:

Amoxycillin?should?not?be?given?to?patients?with?infectious?mononucleosis,?lymphatic?leukaemia?and?

patients?with?hyperuricaemia?being?treated?with?allopurinol,?since?these?patients?appear?to?have?a?

higher?incidence?of?skin?rashes.
Anaemia,?thrombocytopenia,?thrombocytopenic?purpura,?eosinophilia,?leukopenia?and?agranulocytosis?

have?been?reported?during?therapy?with?the?penicillins.?These?reactions?are?usually?reversible?on?

discontinuation?of?therapy?and?are?believed?to?be?hypersensitivity?phenomena.

Amoxycillin?may?decrease?the?efficacy?of?oestrogen-containing?oral?contraceptives?and?it?may?also?affect?the?absorption?of?other?drugs?due?to?its?effect?on

?the?gastro-intestinal?flora.
Safety?of?use?during?pregnancy?has?not?been?established.


STORAGE?INSTRUCTIONS:
Store?below?25°C.?Protect?from?mositure.?Keep?out?of?reach?of?children.

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