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Antipyretic - Analgesic Adco - Diclofenac Medicinal Tablets 25MG 50MG 75MG

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Description

ADCO-DICLOFENAC ?Tablets 25MG 50MG 75MG ?Antipyretic-analgesic 10*10& acute;s / Box

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ADCO-DICLOFENAC 50?mg Tablets

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COMPOSITION:

Each enteric-coated tablet contains 25?mg or 50?mg?diclofenac?sodium.
Sugar free.

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PHARMACOLOGICAL?ACTION:

Diclofenac sodium is a non-steroidal compound, a phenylacetic acid derivative, with analgesic, antipyretic and anti-inflammatory effects. Diclofenac sodium inhibits the biosynthesis and release of prostaglandins, which are known to be implicated in the pathogenesis of inflammation, pain and fever. ADCO-DICLOFENAC Tablets are enteric-coated so that absorption occurs in the gastrointestinal tract to give peak plasma concentrations approximately 2 hours after ingestion. There is at least 99% binding to plasma-proteins and excretion of metabolites is mainly in the urine.?

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INDICATIONS:

Inflammatory and degenerative forms of rheumatism, rheumatoid arthritis, ankylosing spondylitis, osteo-arthrosis, painful post-operative and post-traumatic inflammation and swelling and dysmenorrhoea.

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CONTRA-INDICATIONS:

Diclofenac sodium is contra-indicated in patients with known hypersensitivity to diclofenac and in patients who respond to aspirin and aspirin-type drugs with sensitivity reactions like asthma, acute rhinitis and urticaria. Diclofenac sodium is absolutely contra-indicated in patients with peptic ulceration or a history of such ulceration, and should be used with caution in patients with renal or hepatic insufficiency.

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PREGNANCY AND LACTATION:
The safe use of ADCO-DICLOFENAC in pregnancy has not been demonstrated.
Regular use of NSAID’s during the third trimester of pregnancy may result in premature closure of the foetal ductus arteriosus in utero and possibly in persistent pulmonary hypertension of the newborn. The onset of labour may be delayed and its duration increased.

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DOSAGE?AND?DIRECTIONS?FOR?USE:

Usual Adult Dose:
25 to 50?mg taken three times daily. The tablet must be taken whole during or after meals. Initially this dose may be increased to 150?mg daily and may be reduced to 75 to 100?mg daily in milder cases or for long-term and maintenance therapy. Diclofenac sodium is not recommended for use in children as safety and efficacy have not been established



SIDE?EFFECTS?AND?SPECIAL?PRECAUTIONS:

In view of the product’s inherent potential to cause fluid retention, heart failure may be precipitated in some compromised patients.
Gastric or intestinal ulceration with associated bleeding has been reported - ADCO-DICLOFENAC therapy should be discontinued immediately in such cases. Skin rashes and gastro-intestinal disturbances may occur. Headache, dizziness, oedema, nervousness, pruritus, tinnitus, insomnia, blurred vision and other ocular reactions, peripheral oedema, malaise, jaundice, elevated transaminase levels, drowsiness and hypersensitivity reactions (eg. bronchospasm) have occurred. Blood counts and monitoring of hepatic and renal function are advised during prolonged therapy with ADCO-DICLOFENAC as blood dyscrasias have been reported. ADCO-DICLOFENAC should be given with care to patients with bleeding disorders, cardiovascular disease, and in those who are receiving coumarin anticoagulants. Patients who are sensitive to aspirin generally should not be given ADCO-DICLOFENAC.

STORAGE?INSTRUCTIONS:

Store below 25°C. Protect from light and moisture. Keep out of reach of children.

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