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Tamoxifen, Nolvadex

Active Pharmaceutical Ingredients;Protein Kina

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Description

Tamoxifen, Nolvadex
Basic information
CAS: 10540-29-1
MF: C26H29NO
MW: 371.51
EINECS: 234-118-0
Product Categories: Active Pharmaceutical Ingredients;Protein Kinase Inhibitors and Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Aromatics
Mol File: 10540-29-1.mol

Chemical Properties
White Crystalline Solid
mp 97-98 °C(lit.)
storage temp. 2-8°C
Usage
A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

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