Pharmaceutical Products
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1.Pramoxine Hydrochloride
English Synonyms: proctofoam; Pramoxine HCL; Praxomine Hydrochloride; Tronothane Hydrochloride; ; pramocaine Hydrochloride;
CAS: 637-58-1
EINECS Number: 211-293-1
Formula: C17H28ClNO3
MW: 329.8621
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 ° C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Assay:99.5%
Appearance: white or almost white crystalline powder
Uses:Local anesthetics
2. Description:
Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
3. Applications:
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
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