Pharmaceutical Products
Description
Quick Details:
Product Name: Candesartan Cilexetil
CAS No.: 145040-37-5
MF: C33H34N6O6
MW: 610.66
Specification: CP, USP
Appearance: White to off-white crystalline powder.
Usage: Ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.
Description:
Candesartan Cilexetil is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.
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Taizhou Tianrui Pharmaceutical Co.,Ltd
nti-tuberculous, Anti-hypertensive, Anti-hyperlipidemic, Anti-bacterial, and Vitamin derivatives APIs and their intermediates productions.
Address: No.168,Xingtai Street,Jiaojiang Zone, Taizhou City, Zhejiang 318000,
Taizhou City, Zhejiang
China, 318000
Tel: +86-(576)-88201638
Fax: +86-(576)-88603302
