Biochemical
Description
Name: Brinzolamide
CAS: 138890-62-7
Assay: 99%
Shelf life: 2years
Apperance: White Crystalline Powder
Introduction:
Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Carbonic anhydrase is found primarily in erythrocytes(but also in other tissues including the eye). It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II (CA-II).
Pharmacodynamics:
Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.
Applications:
Use for the treatment of open-angle glaucoma and raised intraocular pressure due to excess aqueous humor porduction.
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