Pharmaceutical Products
Description
Sodium Stearyl Fumarate CAS 4070-80-8
Quick Detail:
Product Name: Sodium Stearyl Fumarate
Synonyms: Quartz (SiO2);Rose quartz;silica,crystalline(asrespirable;silica,crystalline(asrespirabledust);Silicon oxide, quartz;CRYSTALLINE SODIUM POTASSIUM ALUMINOSILICATE;HYDRANAL(R)-MOLECULAR SIEVE;ALUMINUM SODIUM SILICATE.
CAS: 4070-80-8
MF: C22H39NaO4;
MW: 390.53
EINECS:223-781-1;
Description
Sodium stearyl fumarate is a water-soluble lubricant used in the pharmaceutical industry for compressing tablets (& quot;tableting& quot;). Sodium stearyl fumarate is an inert, hydrophilic, tablet lubricant, useful in situations where other lubricating agents (i.e., magnesium stearate) fail to provide tablets of adequate stability, hardness, content uniformity, disintegration and dissolution rate.
Usage of Sodium stearyl fumarate
The ability of sodium stearyl fumarate to reduce friction and adhesion to the punches was investigated as well as its influence on the tablet strength and the disintegration time. The effect of lubricant concentration, particle size and the mixing time was investigated using lactose and sodium chloride as tablet materials. A direct comparison with magnesium stearate in 6 tablet formulations was also made. The friction during compression and ejection of the tablets was measured in an instrumented tablet machine. Sodium stearyl fumarate reduced the friction and the adhesion to about the same degree as magnesium stearate and had also about the same influence on tablet strength and disintegration. The particle size of sodium stearyl fumarate was of great importance and all effects correlated better to the surface area than to the weight fraction. Prolonged mixing improved its lubricating effect and had no effect on the disintegration but reduced the strength of sodium chloride tablets. Sodium stearyl fumarate appears to be a good alternative to magnesium stearate.
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Nanjing Bangnuo Biotechnology Co., Ltd.
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