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Palmitoylethanolamide CAS 544-31-0 as Natural Painkiller (jerryzhang001@chembj.com)

544-31-0

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Description

Palmitoylethanolamide CAS 544-31-0 as Natural Painkiller

Quick Detail:
Product Name: Palmitoylethanolamide
Synonyms:
N-(2-HYDROXYETHYL)HEXADECANAMIDE;N-HEXADECANOYLETHANOLAMINE;PEA PALMIDROL;PALMITYLETHANOLAMIDE;PALMITOYLETHANOLAMIDE;PALMITOYLETHANOLAMIDE N-(2-HYDROXYETHYL)HEXADECANAMIDE;n-(2-hydroxyethyl)-hexadecanamid;Palmidrol

CAS: 544-31-0;
MF: C18H37NO2;
EINECS: 208-867-9;
MW: 299.49.

Description:
Palmitoylethanolamide?(PEA) is an endogenous?fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha?(PPAR-alpha).

PEA also has affinity to cannabinoid-like G-coupled receptors?GPR55?and GPR119. PEA cannot strictly be considered a classic?endocannabinoid because it lacks affinity for the cannabinoid receptors?CB1?and?CB2. However, the presence of PEA (and other structurally related?N-acylethanolamines) has been known to enhance anandamide activity by a so-called & quot;entourage effect& quot;.

Several papers have demonstrated that an imbalance of the endocannabinoid system (ECS) and alterations in the levels of PEA occur in acute and chronic inflammation. For instance during beta-amyloid-induced neuroinflammation the deregulation of cannabinoid receptors and its endogenous ligands accompanies the development and progression of disease.

PEA has been shown to have?anti-inflammatory, anti-nociceptive, neuroprotective, and?anticonvulsant?properties.

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