Biochemical
Description
Product Name Alendronate Sodium
CAS 121268-17-5
MF C4H12NO7P2.Na.3H2O
MW 325.12
Assay 99.5%
Appearance White Crystalline Solid
Categories Miscellaneous Biochemicals;All Inhibitors;Osteoporosis;Inhibitors;
Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous
Compounds;Phosphorylating and Phosphitylating Agents;REQUIP
Synonyms G-704650;ALENDRONATE SODIUM SALT;ALENDRONATE, SODIUM SALT TRIHYDRATE;ALENDRONATE SODIUM TRIHYDRATE;ALENDRONNATE SODIUM TRIHYDRATE;
ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE;
ADRONAT;4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE
Usage A bisphosphonate used as a bone reabsoption inhibitor ; dopamine receptor agonist, antiParkinsonian
Description :
Alendronate sodium is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts.
It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM).
It efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 μM). And it also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
Application :
Alendronate sodium is a bisphosphonate drug used for osteoporosis and several other bone diseases.
And used in the treatment of osteoporosis in postmenopausal women, in order to prevent hip and spine fractures (vertebral compression fractures) . Applies to male osteoporosis in order to increase bone mass.
It has been used for prevention and treatment of corticosteroid-associated osteoporosis together with supplements of calcium and vitamin D, and used for paget& acute;s disease.
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