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1030377-33-3;MK-4305;Suvorexant; MK 4305
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1030377-33-3;MK-4305;Suvorexant; MK 4305

1030377-33-3;MK-4305;Suvorexant; MK 4305
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Description

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors respond to orexin signaling, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R) with partially overlapping nervous system distributions. Genetic studies suggest orexin receptor antagonists could be therapeutic for insomnia and other disorders with disruptions of sleep and wake. Suvorexant (MK-4305) was found.
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1030377-33-3, MK-4305;Suvorexant; MK 4305,

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